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Extracellular membrane vesicles from Clostridium perfringens as a vaccine strategy in chickens against necrotic enteritis

2021 CPRF
Necrotic enteritis in broiler chickens is characterized by increased mortality and severe necrosis of the intestinal mucosa. This economically important disease is caused by the Gram-positive bacteria Clostridium perfringens and is commonly controlled by antimicrobial feed additives. However, due to the reduction of antibiotic use in the Canadian poultry industry, new alternatives must be found to prevent necrotic enteritis. It has been shown over the past few years that most Gram-negative bacteria can shed extracellular vesicles (EVs) mostly during cell growth. Observed EVs are spherical structures with average diameter of 20 to 400 nm. Their membranes contain phospholipids mixed with proteins and the vesicular lumen may contain various compounds such as proteins, RNA, DNA and peptidoglycans. These EVs have also been demonstrated to be immunogenic and protective against various bacterial diseases. Interestingly, we have been able to produce EVs from Clostridium perfringens pathogenic strains using various protocols and our next objective is to verify if membrane vesicles can stimulate chicken systemic and mucosal immunity
Tags :
Clostridium perfringens,necrotic enteritis,vaccine potential
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MSc Student

University of Montreal

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