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In ovo characterization of innate immune stimulants for control of yolk sac infection in young chicks

2022 CPRF,Health & Immunity
Omphalitis, or yolk sac infection (YSI), in young chicks, is the major cause of ECM, with most death occurring within 24 h of hatching and peaking at 5 to 7 days. These infections may cause up to 1.3% mortality per week during the first two weeks, lack of uniformity in size, and greater susceptibility to other infectious diseases in young birds. Currently, YSI is managed by heavy culling and administration of antibiotics via in ovo injection or post-hatch. However, consumer demand for antibiotic-free products and the reduction of antibiotic-resistant bacteria has prompted the poultry industry to search for alternative products. Although multiple studies have been performed for the development of vaccines as well as antimicrobial alternatives, there are no commercially available alternatives for the prevention and control of mortalities due to YSI and other bacterial infections in young chicks. The current study aimed at testing in ovo effects of some innate immune stimulants including unmethylated cytosine-phosphate-guanosine dinucleotide -containing oligodeoxynucleotides (CpG ODN), polyinosinic–polycytidylic acid (poly I:C), cyclic polyphosphazene 75B (CPZ75B), and avian antimicrobial peptides control of early chick mortality (ECM) due to YSI caused by avian pathogenic E. coli (APEC) in young chicks.
Tags :
chicks,Immunity,yolk sac infection
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Vaccine and Infectious Disease Organization (VIDO)

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