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Performance of distinct microbial based solutions on a Campylobacter infection challenge in poultry

2021 CPRF,Gut Health, Antibiotic Alternatives & Management
Antibiotic growth promoters (AGPs) are commonly used within poultry production to improve feed conversion, bird growth, and reduce morbidity and mortality from clinical and subclinical diseases. Due to the association between AGP usage and rising antimicrobial resistance, the industry explores new strategies including the use of probiotics and other microbial based interventions to promote the development of a healthy microbiome in birds and mitigate against infections associated with food safety and food security. While previous studies have largely focused on the ability of probiotics to protect against Clostridium perfringens and Salmonella enterica, much less is known concerning their impact on Campylobacter jejuni, a near commensal of the chicken gut microbiome that nevertheless is a major cause of food poisoning in humans. Here we compare the efficacy of four commercial probiotic products: a single strain bacteria (Pediococcus acidilactici), a single strain yeast (Saccharomyces cerevisiae boulardii) and two complex consortia (Aviguard and MCH1) to bacitracin, a commonly used AGP, to reduce C. jejuni infection in poultry. Cecal samples were harvested at 30- and 39-days post hatch to assess Campylobacter burden and examine their impact on the gut microbiome. While probiotic treatments did not significantly decrease C. jejuni burden relative to controls, the yeast-based and complex consortia resulted in significant decreases relative to treatment with bacitracin. Analysis of 16S rDNA profiles revealed a distinct microbial signature associated with each probiotic treatment. For example, treatment with Aviguard and MCH1 increased the relative abundance of Bacteroidaceae and Rikenellaceae respectively. Furthermore, Aviguard promoted a less complex microbial community compared to other treatments. Depending upon the individual needs of the producer, our results illustrate the potential of each probiotic treatment to serve flock-specific requirements.
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Campylobacter infection
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Hospital for Sick Children

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