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The role of chicken calcium-sensing receptor and calcium homeostasis in laying hens

2021 CPRF
Laying hens have a high demand for calcium to form eggshells during the active egg-laying period. Calcium is the most important mineral in the structure of bones and eggshells. However, only 60% to 75% of the eggshell calcium can be provided by the feed, and the remainder must be supplied from bone storage. Osteoporosis is a big concern in the layer industry because it is associated with pain, reduced egg production, reduced eggshell quality, and animal welfare issues. As human calcium-sensing receptor has been recognized as a therapeutic target in osteoporosis, to prevent or attenuate osteoporosis in laying hens, chicken calcium-sensing receptor (cCaSR) is worth being investigated. The cCaSR and chicken vitamin D receptor (cVDR) were demonstrated to widely distribute in the kidney, proventriculus, duodenum, jejunum, ileum, colon, cecum, shell gland, and tibia of laying hens at peak laying, middle laying, and late laying. In addition, similar to human CaSR, L-tryptophan and inorganic phosphate were also cCaSR modulators, acting as positive and negative allosteric modulators, respectively, with biased agonism and antagonism in vitro. The results also provided theoretical evidence that L-tryptophan and inorganic phosphate could be used as potential nutritional ligands to prevent or attenuate chicken osteoporosis through the cCaSR modulation.
Tags :
calcium homeostasis,eggshell quality
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PhD Candidate

University of Manitoba

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